T.C. SAĞLIK BAKANLIĞI Sakarya İl Sağlık Müdürlüğü Sakarya Eğitim ve Araştırma Hastanesi

T.C. SAĞLIK BAKANLIĞI Sakarya İl Sağlık Müdürlüğü Sakarya Eğitim ve Araştırma Hastanesi

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Prof.Dr. Birsen AYDEMİR

Güncelleme Tarihi: 28/07/2021

Adı Soyadı  :
Prof.Dr. Birsen AYDEMİR
Ünvanı        : Profesör
Bölüm         : Biyofizik
Yabancı Dil : .....

İstanbul Üniversitesi Fen Fakültesi, Biyoloji (Lisans) 
• İstanbul Üniversitesi Sağlık Bilimleri Enstitüsü Cerrahpaşa Tıp Fakültesi, Biyofizik EABD (Doktora)

İş Deneyimi:

• Sakarya Üniversitesi Tıp Fakültesi (halen)
• İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi

Uzmanlık Alanları:
• Moleküler Biyofizik

Akademik ve Bilimsel Yayınlar:

A1. Yavuz, N., Unal, E., Memisoglu, K., Krand, O., Kızıler, A.R., Aydemir, B., Kusaslan, R., Doğan, M., Gunes, P.ve Titiz, I, “Plasma leptin levels in rats with pancreatitis”, Tohoku J Exp Med  204 (4), 243-248 (2004).

A2. Titiz, İ, Krand, O., Unal, E., Yavuz, N., Kusaslan, R, Dogan, M., Uzun, H., Kızıler, A.R., Aydemir, B., Genc, H., Aydın, S.ve Simsek, G, “Oxidative stress in portal hypertension-induced rats with particular emphasis on nitric oxide and trace metals”, World J Gastroenterol,11(23), 3570-3573 (2005).

A3. Yavuz, N,Unal, E, Dogan, M, Kızıler, A.R., Aydemir, B ve Titiz İ, “Serum free prostate-specific antigen and zinc levels in experimental acute pancreatitis”, Biol Trace Elem Res,106,205-209 (2005).

A4.Aydemir, B., Kızıler, A.R., Onaran, I, Alıcı, B.,Özkara, H. ve Akyolcu, M.C, “Impact of Cu and Fe concentrations on oxidative damage in male infertility”, Biol Trace Elem Res,112 (3), 193-204 (2006).

A5. Yapici, G., Can, G., Kiziler, A.R., Aydemir, B., Timur, I.H.ve Kaypmaz A, “Lead and cadmium exposure in children living around a coal-mining area in Yatağan, Turkey” Toxicology and Industrial Health,22, 357-362 (2006).

A6. Unal, E., Turkmen, F., Sevinc, C., Kiziler, A.R., Aydemir B. ve Titiz I, “Outcome of renal allograft in Turkish patients with pretransplantation hepatitis C virus infection”, Transplantation Proceeding,38(10), 3448-3450 (2006).

A7. Aydemir, B., Onaran, I., Kızıler, A.R., Alıcı, B. ve Akyolcu, M.C, “Increased

oxidative damage of sperm and seminal plasma in men with idiopathic infertility is higher in patients with glutathione S-transferase M1 (GSTM1) null genotype”, Asian J Androl9(1), 108-115 (2007).

A8. Ünüvar, E., Ahmadov, H., Kızıler, A.R., Aydemir, B., Toprak, S., Ülker, V. ve Ark, C, “Mercury Levels in Cord Blood and Meconium of Healthy Newborns and Venous Blood of Their Mothers: Clinical, Prospective Cohort Study”, Science of the Total Environment374(1), 60-70 (2007).

A9. Aydemir, B., Kızıler, A.R. ve Akyolcu M.C., “Determination of optimal lithium concentration in fractions of blood in atomic absorption spectrophotometer”, Trace Elements and Electrolytes24(2), 87-91 (2007).

A10. Kayalı, R., Cakatay, U., Kızıler, A.R. ve Aydemir, B, “Effect of alpha-lipoic acid supplementation on trace element levels in serum and in postmitotic tissue in aged rats” Med Chem, 3(3), 297-300 (2007).

A11.Kızıler, A.R., Aydemir, B., Onaran, I., Alıcı, B., Ozkara, H., Gulyasar, T. ve Akyolcu, M.C, “High Levels of Cadmium and Lead in Seminal Fluid and Blood of Smoking Men are Associated with High Oxidative Stress and Damage in Infertile Subjects” Biol Trace Elem Res,120(1-3), 82-91 (2007).

A12. Aydemir, B., Onaran, I., Kiziler, A.R., Alici, B.ve Akyolcu, M.C, “The influence of oxidative damage on viscosity of seminal fluid in infertile men”, J Androl,29(1), 41-46, (2008).

A13. Çakatay, U., Kayalı, R., Kızıler, A.R. ve Aydemir, B, “Postmitotic tissue selenium and manganese levels in alpha-lipoic acid-supplemented aged rats”, Chem Biol Interact,171(3), 306-311 (2008).

A14. Kızıler, A.R., Aydemir, B., Gulyasar, T., Unal, E. ve Gunes, P, “Relationships among Iron, Protein Oxidation and Lipid Peroxidation Levels in Rats with Alcohol-induced Acute Pancreatitis”, Biol Trace Elem Res, 124(2), 135-143 (2008).

A15. Akaylı, T., Timur, G., Aydemir, B., Kızıler, A.R., Coskun, O., Albayrak, G.ve Arican, E, “Characterization of Vibrio alginolyticus isolates from diseased cultured Gilthead Sea Bream, Sparus aurata”The Israeli Journal of Aquaculture-Bamidgeh,60(2), 89-94 (2008).

A16.Onaran, I., Sencan, S., Demirtaş, H., Aydemir, B., Ulutin, T. ve Okutan, M, “Toxic-dose warfarin-induced apoptosis and its enhancement by gamma ionizing radiation in leukemia K562 and HL-60 cells is not mediated by induction of oxidative stress”, Naunyn Schmiedebergs Arch Pharmacol, 378, 471-481 (2008).

A17. Kacakci, A., Aslan, İ., Toplan, S., Oysu, C., Aslan, O. ve Aydemir, B, “Significance of the Counteracting Oxidative and Antioxidative Systems in the Pathogenesis of Laryngeal Carcinoma”, Journal of Otolaryngology-Head & Neck Surgery, 38(2), 172-177 (2009).

A18. Arslan, C., Altan, H., Beşirli, K., Aydemir, B., Kiziler, A.R. ve Denli, S, “The Role of Oxidative Stress and Antioxidant Defenses in Buerger Disease and Atherosclerotic Peripheral Arterial Occlusive Disease”,Ann Vasc Surg,24(4), 455-460 (2010).

A19. Or, E.M., Kayar, A., Gonul, R., Dokuzeylul, B., Kiziler, A.R., Aydemir, B., Aksu A., Parkan , C., Morkoc, T. ve Barutcu B, “ The clinical efficiency of Minerasol® a new trace element combination on sheep”, Journal of Animal and Veterinary Advances, 9(2), 414-417 (2010).

A20. Kiziler, A.R., Aydemir, B., Guzel, S., Alici, B., Ataus, S., Tuna, M.B., Durak, H. ve Kilic, M, “May the level and ratio changes of trace elements be utilized in identification of disease progression and grade in prostatic cancer?” , Trace Elements and Electrolytes, 27(2), 65-72 (2010).

A21. Akayli, T., Timur, G., Albayrak, G. ve Aydemir, B., Identification and Genotyping of Vibrio ordalii: A Comparison of Different Methods, The Israeli Journal of Aquaculture-Bamidgeh,62(1), 9-18 (2010).

A22. Or,E.M. Kayar, A., Gonul, R., Dokuszeylul, B., Kiziler, A.R., Aydemir, B., Aksu, A., Parkan, C., Morkoc, T., ve Barutcu, B., “The clinical efficiency of Minerasol a new trace element combination for cows”The Indian Veterinary Journal, 87(6), 554-555 (2010).

A23. Onaran I, Aydemir B, Kızıler AR, Demityurek T, Alıcı B,  “Relationships between levels of estradiol and testosterone in seminal plasma and GSTM1 polymorphism in infertile men” Archives of Andrology, 53, 13-16 (2007) (D3 daha genişletilmiş makale)


A24. Arslan, C., Altan, H., Akgün, O.O., Kiziler, A.R., Aydemir, B., Güzel, S., Besirli, K., ve Bozkurt, A.K., “Trace elements and toxic heavy metals play a role in Buerger disease and atherosclerotic peripheral arterial occlusive disease” Int Angiol, 29(6), 489-495 (2010).

A25. Guzel S., Kiziler L., Aydemir B.,Alici B., Ataus S., Aksu A. ve Durak H. “ Association of Pb, Cd, and Se Concentrations and Oxidative Damage-Related Markers in Different Grades of Prostate Carcinoma” Biol Trace Elem Res,145(1), 23-32 (2012).


A26. Besirli K., Aydemir B., Arslan C., Kiziler A.R., Canturk E. Ve Kayhan B. “Calcium dobesilate may improve hemorheology in patients undergoing coronary artery bypass grafting” Rev Bras Cir Cardiovasc, 27(2),260-266 (2012).

A27. Unal E, Eris C, Kaya B, Uzun H, Cavdar F, Yildar M, Kiziler AR, Aydemir B, Gunes P, Kutanis R, Titiz I. “Paraoxonase and arylesterase activities, lipid profile, and oxidative damage in experimental ischemic colitis model”. Gastroenterol Res Pract, 2012:979506. doi: 10.1155/2012/979506.

A28.Guzel S, Seven A, Guzel EC, Buyuk B, Celebi A, Aydemir B. “Visfatin, Leptin, and TNF-α: Interrelated Adipokines in Insulin-Resistant Clinical and Subclinical Hypothyroidism”. Endocr Res, 38(3), 184-194 (2013).

A29. Celik C, Bastu E, Abali R, Alpsoy S, Guzel EC, Aydemir B, Yeh J.The relationship between copper, homocysteine and early vascular disease in lean women with polycystic ovary syndrome”.Gynecol Endocrinol, 29(5):488-91 (2013).

A30. Tuten A, Aydemir B, Oncul M, Kiziler AR, Acıkgoz AS, Korkmaz GG, Sozer V, Uzun H. “The association of lectin-like oxidized LDL receptor 1 (LOX-1) K167N and 3'UTR188CT polymorphisms with maternal plasma soluble LOX-1 levels and preeclampsia risk in Turkish population”. Arch Gynecol Obstet, 291(3):563-71 (2015) doi: 10.1007/s00404-014-3457-4.

A31. Cinemre H, Serinkan Cinemre BF, Çekdemir D, Aydemir B, Tamer A, Yazar H. “Diagnosis of vitamin B12 deficiency in patients with myeloproliferative disorders”. J Investig Med. 2015 Apr;63(4):636-40. DOI: 10.1097/JIM.0000000000000187

A32. Kiziler AR, Aydemir B, Guzel S, Yazici CM, Gulyasar T, Malkoc E, Acar A. “Comparison of Before and After Varicocelectomy Levels of Trace Elements, Nitric Oxide, Asymmetric Dimethylarginine and Malondialdehyde in the Seminal Plasma and Peripheral and Spermatic Veins.Biol”. Trace Elem Res. 167:172-178 (2015). DOI:10.1007/s12011-015-0303-x.

A33. Aydemir B, Akdemir R, Vatan MB, Cinemre FB, Cinemre H, Kiziler AR, Bahtiyar N, Buyukokuroglu ME, Gurol G, Ogut S. “The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture”. Biol Trace Elem Res. 167:179-186 (2015). DOI:10.1007/s12011-015-0307-6.

A34. Aydemir B, Baykara O, Cinemre Serinkan FB, Cinemre H, Tuten A, Kiziler AR, Akdemir N, Oncul M, Kaya B, Sozer V, Erkorkmaz U, Uzun H. “LOX-1 gene variants and maternal levels of plasma oxidized-LDL and malondialdehyde in patients with Gestational Diabetes Mellitus” Arch Gynecol Obstet. 293 (3):517-527 (2016). DOI: 10.1007/s00404-015-3851-6.

A35. Serinkan Cinemre FB, Cinemre H, Karacaer C, Aydemir B, Nalbant A, Kaya T, Tamer A. “Midkine in vitamin D deficiency and its association with anti-Saccharomyces cerevisiae antibodies”. Inflamm Res. 65(2):143-50 (2016). doi: 10.1007/s00011-015-0898-6.

A36.Aydemir B., Cinemre Serinkan F.B, Cinemre H., Kiziler A.R., Akdemir R.,  Vatan M.B., Kiliç M.A., Bahtiyar N., Akkoyun DC. ”Evaluation of metallothionein-1, metallothionein-2, lipid peroxidation and trace elements status in the progression of the spontaneous mitral chordae tendineae rupture patients”.Trace Elements and Electrolytes, 33(4):162-170 (2016). DOI 10.5414/TEX01452

A37.Oner T, Arslan C, Yenmis G, Arapi B, Tel C, Aydemir B, Sultuybek GK. Association of NFKB1A and microRNAs variations and the susceptibility to atherosclerosis.J Genet. 2017 Jun;96(2):251-259.

A38.Atalay H, Boyuk B, Guzel S, Altay M, Kızıler AR, Aydemir B. “Serum trace elements in type 2 diabetes mellitus” Acta Medica Mediterranea 2017; 33(5):795-800

A39.Fatma Behice Serinkan Cinemre, Birsen Aydemir, Tevfik Gulyasar, Hakan Cinemre, Abdullah Tuten et al. Roles of selenoprotein K and selenium status in the etiopathogenesis of preeclampsia: Their relationships with maternal lipid peroxidation, oxidative DNA damage, and glutathione peroxidase. Trace Elem Elect, DOI: 10.5414/TEX01512, 2017-11-20. 

A40. F. Behice Serinkan Cinemre, Hakan Cinemre, Ayse Yücel, Sevgin Degirmencioglu, Abdullah Tüten, M. Aytaç Yüksel, Nevin Yılmaz, Tevfik Gulyasar, Mustafa Yıldız, Nurten Bahtiyar, Ali Rıza Kızıler, and Birsen Aydemir.” The role of selenoprotein P and selenium in the etiopathogenesis of gestational diabetes mellitus: Association with selenoprotein P1 gene (rs3877899) polymorphism”. DOI: 10.5414/TEX01527, 2018.  

A41. S Guzel, FBS Cinemre, EC Guzel, V Kuçukyalcin, AR Kiziler, C Cavusoglu, T Gulyasar, H Cinemre, B Aydemir “Midkine Levels and its Relationship with Atherosclerotic Risk Factors in Essential Hypertensive Patients” DOI: 10.4103/njcp.njcp_309_17, 2018.

A42. Cinemre FBS, Cinemre H, Erdoğan E, Dilaveroglu N, Tüten A, Kaya B, Yılmaz N,  Gulyasar T, Yıldız M, Bahtiyar N,  Kızıler AR, Aydemir B.  Association of selenoprotein W1 (rs3786777) polymorphism, maternal plasma selenoprotein W (SelW), and selenium levels in patients with pre-eclampsia. Trace Elem Elect ,36(2):61-67, DOI: 10.5414/TEX01542, 2019.

A.43 Bahtiyar N, Onaran İ, Aydemir B, Baykara O, Ağaoğlu F, Toplan S, Akyolcu MC. Monitoring of platelet function parameters and microRNA expression levels in patients with prostate cancer treated with volumetric modulated arc radiotherapy. Oncology Letters 2018;16:4745-4753.

A44. Aydemir B, Cinemre FBS, Cinemre H, Tüten A, Yüksel MA, Yılmaz N, Kaya B, Akdemir N, Erdogan E, Madazlı R. Paraoxonase 1 (PON1) Q192R and L55M polymorphisms, lipid profile, lipid peroxidation and lipoprotein-a levels in Turkish patients with pregnancy-related disorders, Gynecological Endocrinology, 2019; May;35(5):417-421. DOI: 10.1080/09513590.2018.1532990

A45. CEKDEMIR D, Serinkan CINEMRE FB, AYDEMIR B, DILAVEROGLU N, CEKDEMIR YE,  GUNDUZ M,  CINEMRE H.  Effects of Immune Complexes on Holotranscobalamine Assay of Vitamin B12 Deficiency in Myeloproliferative Disorders. International Journal of Hematology and Oncology, 29:31-31, 2019,  doi: 10.4999/uhod.193047

A46. Saribal D, Hocaoglu-Emre FS, Aydemir B, Akyolcu MC, Determination of relationship between lipid peroxidation, antioxidant defence, trace elements, and hemorheology in COPD. Trace Element and electrolytes, 36(3): 131-136, 2019,DOI 10.5414/TEX01567.

A47. Karacaer C, Cinemre FB, Cinemre H, et al. Acute nonvariceal upper gastrointestinal bleeding related to oxidative damage, ischemia, and trace element status. Trace Element and electrolytes, 2020; 37(3):114-123. DOI 10.5414/TEX01627

A48. Akdemir N, Cinemre FB, Cinemre H, Sevinc L, Aydemir B, Coban B, Cevrioglu AS, Ozden S. Polymorphism of the Oxytocin Receptor (OXTR) Gene Affects the Circulating Oxytocin Receptor Levels in Late-Term Pregnancy in a Turkish Population. Gynecol Obstet Invest 2020;85(4):343-351. DOI: 10.1159/000508074

A49.Bahtiyar N., Cinemre F.B.S., Cinemre H., Kızıler A.R., Atagun M.I., Gulyaşar T., Aydemir B. Thyroid dysfunctions due to lithium treatment in bipolar disorder: changes in oxidative stress, trace elements, and hemorheological parameters. J. Elem., 2020: 25(3): 863-878. DOI: 10.5601/jelem.2020.25.1.19342020.

A50.Serinkan Cinemre FB, Cinemre H, Bahtiyar N, Kahyaoğlu B, Ağaç MT, Shundo H, Sevinç L, Aydemir B. Apelin, Omentin-1, and Vaspin in patients with essential hypertension: association of adipokines with trace elements, inflammatory cytokines, and oxidative damage markers. Ir J Med Sci. 2021; 190(1):97-106. doi: 10.1007/s11845-020-02272-w.